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Studies such as LEADER, SUSTAIN-6, and REWIND primarily evaluated major adverse cardiovascular events

Some research supports oral use of BPC-157, especially for gut healing applicationswhich makes sense given that it's derived from a gastric protein

That question returns now in a different form

doi: 10.3389/fendo.2023.1121303 28 KhadilkarAOzaCMondkarSA

At 300 M, AQ and DEAQ decreased cell viability with approximately 15 and 70%

While their mechanisms of action are similar, topical acetyl hexapeptide-8 does demonstrate a lower efficacy than injected Botox, but as researchers note this is to be expected.22 Similar results were found in a small 2013 study, with the total anti-wrinkle efficacy of the Argireline treatment group being 48.9% compared to 0% in the placebo group.23 However, a more recent 2023 study investigating the effects of serum containing Argireline and hyaluronic acid found the results to be not statistically significant.24 This means that more research is needed before claims that Argireline is a true alternative to Botox can be confirmed or denied