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The native IGF-1 produced by your liver has a relatively short half-life because it's quickly bound up by IGF-binding proteins (IGFBPs)

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However, damage to this barriersometimes referred to as intestinal permeability or leaky gutcan allow inflammatory compounds such as bacterial endotoxins to enter the bloodstream

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[14] Clinical significance [edit] The GPx1 allele with five Ala repeats is significantly associated with breast cancer risk