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In cultured human keratinocytes exposed to UVB radiation (a standard oxidative stress model), pre-treatment with 10 nM GHK-Cu resulted in: 2.8-fold increase in glutathione reductase mRNA (the enzyme regenerating reduced glutathione from its oxidized form) 2.3-fold increase in catalase expression (HO decomposition) 1.9-fold increase in ferritin heavy chain (sequestering iron, another Fenton-active metal) 62% reduction in 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, a DNA oxidative damage marker The protective effect disappeared when using copper-free GHK or copper chloride alone, confirming the intact peptide-copper complex is required

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Functional diversity of cysteine residues in proteins and unique features of catalytic redox-active cysteines in thiol oxidoreductases

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Serving Size: 1 suppository Servings per Container: 30 Reduced Glutathione 225 mg Proprietary blend of NAC, Taurine and Reduced Glutathione 12X Suppository Base: The base is a proprietary combination of excipients of plant and fruit butters, medium chain triglycerides, phospholipids, lecithin and arrow root starch

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