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Airlines accommodate it

In some cases, autonomic effects such as increased peripheral vasoconstriction may make the hands and feet feel colder even without a major change in core body temperature

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Head Neck 38(12):1739-1751, 2016

The most common side effects are gastrointestinal (such as nausea, vomiting, or diarrhea), and your physician also watches for less common but serious effects such as pancreatitis

Pushing past your tolerance window creates exactly the kind of GI mess that makes patients quit the protocol entirely