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First, several of these compounds are promoted for their effects on blood vessel growth, and NPR reported FDA raised concerns about the potential to encourage cancer growth. If you have a cancer history, that is not a small footnote
Nat Rev Mol Cell Biol 8(10):761773
Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
These are banned by many sporting organizations, show little proof of effectiveness, and often come with serious side effects.
In the Prenatal THC/stress group, upregulated genes were enriched for startle response, dendritic spine development, and glutamate-receptor binding, whereas downregulated genes involved cellular respiration, plasma membrane receptor complexes, and integrin binding, indicating altered synaptic excitability and cellular energetics
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