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42) In SUSTAIN-6, patients treated with semaglutide had a lower risk of developing or worsening nephropathy, but a higher risk of complications from diabetic retinopathy than those receiving placebo ( In subsequent studies: PIONEER-6 and ELIXA the primary endpoints (death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, hospitalization for unstable angina) were not met in the GLP-1 RAs group, but a significant decrease in glycated hemoglobin was observed

Am J Pathol 182:132141

pylori to gastric mucosa, and induce the synthesis of IL-8, IL-6, TNF- and other inflammatory substances to damage gastric mucosa (Zhang et al., 2022)

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COVID-19 in conjunction with diabetes and obesity (both characterized by severe insulin resistance) has severe clinical consequences 742,743

These molecules are hypothesized to potentially play significant roles in cell growth, migration, and angiogenesis