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The graphic below depicts how specific triggers can lead to certain clinical manifestations, symptoms, and ultimately, autoimmunity

Further analysis, including PCA, differential metabolite screening, and pathway enrichment analysis, was conducted using MetaboAnalyst 6.0 ( 51

The ASMT gene contains 9 exons that generate three alternatively spliced mRNAs encoding proteins of 373 amino acids (isoform 1), 298 amino acids (isoform 2), and 345 amino acids (isoform 3)

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