In a rat contusion model of SCI, exenatide administration significantly elevated the expression of M2-associated markers, including Arginase 1, CD163, and CD206, on day 3 post-injury [65]
Animal experiments confirmed that dural injection of bone marrow mesenchymal stem cell-derived exosomes miR-367-3p significantly reduced the expression of EZH2 in spinal cord tissues of EAE mice, increased the expression of SLC7A11, GPX4, GSH, and SOD, decreased the levels of Fe 2+ and MDA, inhibited spinal cord iron deposition, ferroptosis, and inflammation, and alleviated spinal cord injury (Fan et al., 2023)
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