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In recent years, IDH inhibitors targeting IDH mutants, including ivosidenib and enasidenib (Table 1), have been approved by the Food and Drug Administration to be used in patients with IDH1 or IDH2 mutant recurrent or refractory AML, respectively (Kim, 2017

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Notably, these studies found that simple endothelial cell cultures did not show the same angiogenic response, suggesting that BPC-157 may act as a context-dependent regulator of vascular signaling rather than a direct angiogenic stimulus