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2019, article e000478, pubmed.ncbi.nlm.nih.gov/30899546
Five subjects had severe hypoglycemia requiring assistance, and four experienced hypoglycemic seizures or loss of consciousness on at least one occasion
Its low molecular weight and permeability allow it to reach intracellular enzyme targets directly, which is the property that makes it useful in cell-based metabolic assays
The study confirmed that FOXO4-DRI binds directly to the disordered p53 TAD2 domain and forms a transiently folded complex a disordered-to-ordered transition involving both the FOXO4-derived region of the DRI peptide and its cationic cell permeability element
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