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They do this by: reducing appetite and food reward lowering carbohydrate load slowing gastric emptying so glucose enters the bloodstream more gradually smoothing post-meal glucose rises lowering baseline glucose and insulin exposure over time As chronic insulin exposure falls, the pressure driving ectopic fat storage eases

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Early, in-depth review article that evaluates the similarities and differences between short-acting and long-acting GLP-1R agonists in terms of glucose-lowering efficacy and adverse effects, and discusses the possibilities for utilizing these agents for individualized treatment of T2DM

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95% CI, 0.96-3.85, respectively)