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Nov 7 2025;doi:10.1056/NEJMoa2513032
Studies indicate that activation of TLR2/3/4/5 triggers the NF-B/NLRP3 pathway and the PI3K/Akt/mTORC1 signaling pathway, leading to microglial activation, neuroinflammation, and neuronal damage (147, 148)
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Seiwerth S, Sikiric P, et al
The resulting products are further metabolized to generate ATP through the TCA cycle in conjunction with OXPHOS [170]
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