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After initiation of GLP-1 RA, there was a decrease in HbA1c from 9.5% to 8.6%
In a study of 83 men with obesity, insulin resistance, and symptoms of low testosterone (including erectile dysfunction), those treated with tirzepatide for just two months saw significantly greater improvements than those receiving traditional testosterone replacement therapy (TRT) or lifestyle changes alone
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Those with a BMI of 40 or higher, or 278 pounds for a 5-foot-10 adult, are severely obese. America has been getting more obese over time, according to the CDC
For context, the fat-mass reductions reported in Billon 2024 roughly 25-30% in diet-induced obese mice over 28 days without exercise are large for a preclinical metabolic agent and explain why the "exercise mimetic" label stuck
"Polycystic ovary syndrome - Treatment"
