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More advanced deficiency produces balance problems, weakness in the legs, a sore and inflamed tongue (glossitis), and in severe cases, megaloblastic anemia where red blood cells become abnormally large and inefficient at carrying oxygen
Hepatology 58 , 10841093 (2013)
Thus, hemoglobin metabolism might play a role in iron-overload-driven death of erythrocytes
If symptoms of allergic reactions (including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing) occur, patients must stop taking JANUVIA and seek medical advice promptly [see Warnings and Precautions (5.5)]
Once weekly, subcutaneous, same day each week
Constant mast cell activation across time means the mast cells may struggle to differentiate between what is safe and what is unsafe and therefore, may become highly reactive to foods, supplements, light, noise, heat, exercise, smells, skin care products etc
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