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18,25 GLP-1 Agonists: Molecular Design and Pharmacokinetics Evolution of GLP-1 Agonist Structures The potential benefits of natural GLP-1 is constrained by its rapid breakdown by serum enzymes proteases, primarily dipeptidyl peptidase IV (DPP-IV), along with neutral endopeptidase (NEP), plasma kallikrein, and plasmin

And lipolysis is also affected by many lipid-associated proteins, such as SIRT1, -subunit of PGC-1, fatty acid-binding protein 4 (FABP4), etc

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Two authors (DM and SS) independently reviewed and selected studies for inclusion and subsequently resolved discrepancies by discussion

10.1016/j.arr.2022.101815 108 NethB

Meski begitu, diperlukan lebih banyak studi untuk memastikan klaim ini