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Try to avoid changing the dose by more than 50-100 mg (due to nonlinear pharmacokinetics, the levels may respond more strongly than you would expect)

The primary endpoint was the mean change in HbA1c from baseline to week 52 for tirzepatide relative to insulin lispro (Rosenstock et al., 2023)

This is because tirzepatide is designed to mimic the action of two gut hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are released in response to food intake and help to regulate blood sugar levels

Wegovy (Semaglutide) FDA-approved, injectable weight loss medication FDA-approved, injectable weight loss medication Wegovy is specifically indicated for chronic weight management in adults with obesity or overweight conditions and works by activating the GLP-1 receptors to help reduce appetite and increase feelings of fullness ultimately contributing to weight loss

Have you hit a Wegovy or Ozempic Plateau

If side effects are significant at a new dose, staying at the current level for an additional four weeks or longer before attempting to increase again is the right approach