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In genetically modified mice lacking -opioid receptors, marked alterations in social behavior were observed, including reduced vocalization and diminished social interaction following maternal separation (Cinque et al
Brain Struct
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This was confirmed by shRNA to GCLC, the target of BSO, which increased glutamate levels (Fig
Reported cell-culture systems include dermal fibroblast and keratinocyte monolayers, where the tripeptide is studied in the context of collagen and glycosaminoglycan turnover
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