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Another effect of decreased GI motility is reflux, or GERD
174,175 Several oncogenic mechanisms, such as the transcription factor HIF-1, PI3K/Akt/mTOR pathway and c-Myc, upregulate genes encoding glucose transporters and glycolytic proteins, including GLUT1, GLUT3, and lactate dehydrogenase (LDH)
However, from a practical standpoint, the immediate reduction of appetite is not a universal experience
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