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Lead compounds can be optimized through principles such as bioisosterism, prodrugs, quantitative structure-activity relationships (QSAR), and 3D-QSAR, followed by in silico ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) prediction and physiologically-based pharmacokinetic simulations for preclinical testing

The liver relies heavily on glutathione to facilitate the elimination of toxins, drugs, and metabolic waste products

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Transportation of nutrients thoughout the body