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(PubMed) The same review warns that systemic administration (IV) may shift melanin production, altering skins natural photoprotection and potentially increasing the risk of UV-induced skin damage or cancer a risk especially relevant in sunny climates

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Animal studies serve an important role in identifying potential concerns that warrant human investigation

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Their ability to simultaneously address metabolic risk factors, inflammation, and cellular proliferation positions them as one of the most promising drug classes for interrupting SLD progression (Figure 2)