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My energy improved, and I could actually participate in family activities rather than spending days in bed." Another patient with colorectal cancer shared: "The neuropathy in my hands from chemotherapy was making daily tasks impossible

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This property is exploited by cancer cells, which develop a strong dependence on iron to satisfy the heightened metabolic demands associated with their uncontrolled proliferation and invasive behavior

To counter the enhanced efflux because of proteins like P-gp, overtly expressed in cancer cells, a higher dosage of the chemotherapeutic agent is considered, which would then directly lead to systemic toxicity

However, since pharmacokinetic studies are complex and therefore rare, this issue has not been investigated in more detail yet

611 Clinical research on the treatment of PD by targeting ferroptosis is still in its preliminary stages, and many clinical trials are necessary to validate the efficacy of targeted ferroptosis therapy