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Numbness or weakness accompanies the sensitivity (possible nerve damage rather than sensitivity)

GSTM1 is also the primary enzyme handling oxidative stress byproducts from CYP1A1/CYP1B1-mediated estrogen metabolism including reactive oxygen species generated during the hydroxylation reactions themselves

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Furthermore, oxidative stress can enhance the expression of matrix metalloproteinases (MMPs), enzymes that degrade the extracellular matrix and facilitate tumor invasion and metastasis [116]

The fix isnt more hydration in volume terms