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It involves complex neurobiological mechanisms, including changes in dopamine reward pathways and disruption of hunger-related hormones such as ghrelin and leptin
NICE recommendations for GLP-1 therapy include: For type 2 diabetes (NICE NG28): GLP-1 therapy should only be continued if there is a beneficial metabolic response (HbA1c reduction of 11 mmol/mol [1.0%] and weight loss of 3% of initial body weight at 6 months)
Chronic stress elevates cortisol, which promotes fat storage, particularly visceral adiposity, and can trigger emotional eating behaviors
Besides these potential side effects, the FDA is evaluating reports of suicidal thoughts or actions in patients treated with GLP-1s
This is not a temporary adaptation effect
B., Lee, S
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