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Conversely, formulations at pH 4.5-5.5 (near the isoelectric point) degrade significantly faster

And low levels can accelerate the aging process

Yellowing or Browning If a liquid that was originally clear begins to turn yellow or light brown, it is often a sign of oxidation

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Skin Conditions: Acne : Moderate and severe acne can cause post-inflammatory hyperpigmentation, resulting in dark spots or marks