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GLP-1 agonists affect diverse obesity etiopathogenic processes such as abnormal food intake regulation, adipocyte dysfunction, insulin resistance, adipokine production, inflammation, endothelial dysfunction, lipid metabolism, and oxidative stress

Thus, TMAO-induced inflammation raises the risk of cerebral embolism by causing endothelial damage

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Fixed-dose combinations could optimize outcomes, particularly for patients with advanced disease or those unresponsive to monotherapy

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