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In the SURPASS-2 trial, patients receiving tirzepatide 15 mg weekly experienced triglyceride reductions of approximately 20-25% from baseline, with smaller but clinically meaningful decreases in total cholesterol and LDL cholesterol

Weight loss through any means typically reduces hsCRP, but the magnitude of reduction with GLP-1 based therapies appears to exceed what weight loss alone would predict

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included at least two HbA1C measurements spanning at least one year

Certain medicines are less expensive, but retatrutides clinical profile could merit a higher price if it delivers stronger trial results