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Interestingly, N5 islets with or without NNT activity kept a lower GSIS than BL/6N islets

Its active site is the sulfhydryl group on the cysteine residue, and that group is chemically vulnerable

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PMID 22405895

These three mRNAs collectively encode the G6PD isoform a (545 amino acids) and isoform b (515 amino acids) enzymes