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Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2.4 mg for weight management: a randomised, controlled, phase 1b trial

Their results showed that high-titer AAV exposure induces genotoxicity, immunogenicity, and senescence phenotypes in renal tubular cells, activating the classical NF-B signaling pathway (IL-1/p21-dependent), which leads to fibrotic damage