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Design and structure-activity relationship of Semaglutide analogs

Dysesthesia, an abnormal sensation often described as tingling, burning, or numbness in the skin, appeared in 8.8% of participants on the 9 mg dose and 20.9% on the 12 mg dose, compared to just 0.7% on placebo

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FDA reviewers identified one human study supporting the proposed indication of ulcerative colitis: a decades-old meeting abstract that was never published as a peer-reviewed trial and that used an oral route of administration rather than the injectable or subcutaneous routes that wellness clinics use