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Consistent with the role of cholesterol in the regulation of membrane dynamics, cholesterol loading in mitochondrial membrane results in increased membrane order parameter and in the reduction in the activity of specific membrane carriers, i B via c-SRC and oxidant-dependent cell death

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PMID: 95 RamakrishnanRKBajboujKAl HeialySMahboubBAnsariAWHachimIYet al

Using fatty acids to prolong the duration of the action of peptides and proteins was already a long established technique at Novo Nordisk and elsewhere and had been successfully applied to insulin (insulin detemir) (Knudsen, Lau)