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BNF-aligned regimens are as follows: Without neurological involvement: 1 mg three times a week for two weeks, then 1 mg every three months With neurological involvement: 1 mg on alternate days until no further improvement, then 1 mg every two months Patients with neurological symptoms should be managed promptly, as delays may affect the extent of recovery

10.1002/biof.1687 79 KermanM.KanterM.CokunK

A higher expression of IL-4 and IL-13 is uncovered in the synovial fluid of early RA rather than established RA, which means IL-4 and IL-13 would be the diagnostic biomarkers for early RA patients (84, 85)