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The results are variable according to skin tone from darker to lighter

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A meta-analysis of 12 observational studies (5 prospective cohort studies, 4 case-control studies, and 3 cross-sectional studies) also found blood concentrations of selenium to be inversely associated with risk of stroke (94)

3 Discussion As mentioned above, MMACHC is the biological factor that catalyzes the oxidation-reduction reaction of cyanocobalamin and other B12 forms, facilitating their conversion to either methylcobalamin or adenosylcobalamin, the active forms of vitamin B12

doi: 10.1038/cddis.2014.359 52 DroguerreM.BrotS.VitracC.Benoit-MarandM.BelnoueL.PatrigeonM.et al