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In TRIUMPH-4 trials, 20.9% of patients on 12mg experienced these symptoms, and TRIUMPH-1 confirmed dysesthesia at 12.5% in the general obesity population
In spite of this, a number of studies suggest bile acids can damage the mucosal barrier of the intestinal tract and induce inflammation through relevant mechanisms
Inborn errors of metabolism (e.g., vitamin B6-dependent convulsions or B6-responsive anemia)
It just showed the payoff can be substantial when people stay on protocol long enough
It doesn't dilate blood vessels
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