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HR 1.19, 95% CI 0.91.58), but not for the other DPP-4 inhibitors as in the TECOS study for sitagliptin (HR 1.00, 95% CI 0.831.20) or the CARMELINA study for linagliptin (HR 0.90, 95% CI 0.741.08) (57, 62, 64, 65, 68)

Rather than undermining osteocalcins relevance, these challenges highlight the need for standardized assays, context-aware study designs, and pharmacologic tools that directly modulate osteocalcin signaling

IUBMB Life 71 , 4556 (2019)

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