Participants who started at 1mg and escalated slowly over weeks experienced substantially fewer GI issues than those assigned directly to higher doses
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Both are cytosolic enzymes, whereas DPP-4 is processed by the Golgi apparatus and displayed on the surface of the cell where both GIP and GLP-1 act (Lankas et al., 2005)
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Nausea is the most commonly reported side effect, and antiemetic or prokinetic agents may be recommended for short-term use when it is severe or persistent
The study authors said they hope their findings prompt regulatory agencies and drug manufacturers to update warning labels for the medication and include gastroparesis as a potential side effect