203,204 Recently, in response to specific ligands, including PAMPs/DAMPs (such as heme) and DAMP/cytokine combinations, NLRC5 associates with NLRP12 and cell death molecules to form an NLRC5-PANoptosome complex
Constipation more than doubles
This simultaneous coordination across tissues creates metabolic effects greater than any single-organ response could achieve
Most patients eating less overall will fall short of this without deliberate effort
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Titration: Treatment usually starts at a low dose and gradually increases every few weeks to help minimize side effects and allow the body to adjust