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Probably due to the binding preference of APAP to the active site of each P450 isomer, it is oxidized via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Figure 1)

The apoptotic cells were observed after 3 days culture in both groups

If youre experiencing these symptoms, consider getting your B12 levels checked by a healthcare provider

Monitoring: After starting injections, B12 blood levels and hematologic response are monitored

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Wang Y, Wang D, Wei G, Shao N (2012c) Enhanced co-production of S-adenosylmethionine and glutathione by an ATP-oriented amino acid addition strategy