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Tell your prescribing doctor if you have any of these conditions, which can increase B12 shot side effects: An allergy to cobalt Kidney disease Severe megaloblastic anemia Side Effects from B12 Shots The most common B12 shot side effect is swelling at the injection site

B12 helps with red blood cell formation and anaemia prevention

[10] Long-term use of proton pump inhibitors (PPIs) and H2-receptor antagonists reduces gastric acid, potentially impairing the release of B12 from dietary proteins

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While it shares structural similarities with GHK-CU, the single amino acid difference produces notably different biological effects