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All other standard laboratory chemicals or culture reagents were obtained from Sigma or Thermo Fisher unless otherwise specified
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The binding of insulin with IR causes autophosphorylation of IR [20, 21], activating downstream phosphoinositide-3-kinase (PI3-K)/Akt and mitogen activated protein kinase (MAPK) pathways, which affect the differentiation, energy metabolism and activity of osteocytes [22, 23]
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These medications, which include widely known brands, such as Wegovy and Zepbound, have reported helping patients reduce body weight and lower their risk of serious complications, including cardiovascular disease
& van Grunsven, L
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