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A 2014 study by Nakajima, Nagata, and colleagues published in Archives of Dermatological Research showed that reduced glutathione disrupts intracellular trafficking of tyrosinase to melanosomes, the rate-limiting enzyme in melanin synthesis, attenuating melanization at the cellular level

At 10mg/ml concentration, this requires drawing 0.1-0.3ml, volumes easily measured with U-100 insulin syringes

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With daily dosing over an 8-week protocol, maintaining 10 or more rotation sites ensures adequate tissue recovery between injections