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All animal studies were approved by the State of Bavaria, Germany, or the Insitutional Animal Care and Use Committee of the University of Cincinnati, OH, USA and conducted on the basis of the underlying animal welfare law of the respective countries

Other studies in ApoE / mice demonstrated that TMAO repressed hepatic bile acid synthesis by inhibiting Cyp7a1 expression in the classical pathway of bile acid synthesis and that this inhibition might be mediated by activation of the nuclear receptor FXR and small heterodimer partner (SHP), thus accelerating the formation of aortic AS (Makishima et al., 1999

Clinical Utility of Change in Nonalcoholic Fatty Liver Disease Activity Score and Change in Fibrosis in NAFLD

The answer lies in gene expression