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The discrepancies between experiment and theory throughout the long history of vitamin B12 research are caused by the significant influence of the pseudo-Jahn-Teller effect on its biochemical processes, which cannot be accounted for by either the standard density functional theory (DFT) method [88] or the QM-DFT approximation used in most quantum mechanics/molecular mechanics (QM/MM) studies [2, 89]

Dosage Rates Administration via intramuscular (IM), intravenous (IV) of subcutaneous (below the skin) injection

Blood pressure medications could interact with it too

A U-shaped dose-response and time-of-infusion curve has been documented an important design consideration for DSIP research, as both sub-threshold and supra-threshold doses may produce attenuated effects relative to the optimal dose range