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Requires sustained methyl donor concentrations above baseline for 4872 hours to produce measurable increases in lipid export from hepatocytes

**Pediatric Patients:** Dosage should be determined by a healthcare professional based on the child's age, weight, and clinical condition

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Increased lipase included abnormal lipase, hyperlipasemia, and lipase

The PDUFA (Prescription Drug User Fee Act) date, which is the FDA's deadline to make a decision, would fall approximately 10 months after acceptance

In clinical development programmes, dual agonism has been associated with substantial mean weight loss in selected populations when combined with lifestyle support