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When treatment is titrated toward weight loss rather than glycemic control, average reductions can be much larger, with a trial-level result of 14.9% body weight loss over 68 weeks under a weight-focused escalation protocol
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Of these, two studies ( N = 16 and N = 46, respectively) observed a positive association between the use of exenatide, liraglutide or dulaglutide and weight loss as well as HbA1c at 16 weeks 149 and 1 year 150 , while for the smaller one ( N = 7) this association was not significant 148
It can also cross your blood-brain barrier, which can cause side effects like appetite loss, sexual dysfunction, and fatigue
These protective roles converge on a shared requirement, maintaining energy homeostasis, prompting a closer look at how oligodendrocytes and myelin directly support axonal metabolism through axonglia coupling