DAPA-HF and EMPEROR-Reduced enrolled patients with heart failure with reduced ejection fraction (ejection fraction 40%) who were symptomatic despite guideline-directed medical therapy including renin-angiotensin system blockers, -blockers, and mineralocorticoid receptor antagonists
10.3390/jpm15110518 J Pers Med
K-Dense Web compiled EC50 binding data from ChEMBL and curated literature sources (Coskun et al
Summary: GLP-1 receptor agonist fatigue management strategies include optimising nutrient-dense food intake, maintaining proper hydration, gradual dose titration, managing gastrointestinal symptoms, regular physical activity, and seeking medical review for persistent or severe tiredness
Staying adequately hydrated, avoiding rapid changes in posture, and ensuring a balanced diet can help
Regarding medical procedures, UK guidance does not recommend routine discontinuation of GLP-1 receptor agonists before surgery