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The results showed a significant decrease in the binding of FOXO4 to P53 after FOXO4-DRI treatment (Figure 5A)

Tumor microenvironment-activated ultrasensitive nanoprobes for specific detection of intratumoral glutathione by ratiometric photoacoustic imaging

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(3) Stage-adaptive targeting addresses evolving plaque biology [142], with PBNs unique hemodynamic stability enabling: (i) endothelial activation/neutrophil recruitment during early atherogenesis, (ii) foam cell/collagen fiber targeting in progressive plaques, and (iii) thrombus/necrotic core engagement in unstable lesions [99]

Moreover, the amount of protein species with very low electrophoretic mobility increased, again demonstrating the tendency of the protein to form intermolecular disulfides as already revealed by size exclusion chromatography (Supplementary Fig