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doi: 10.1177/1753425911428964 45 CarrollJABurdickNCReuterRRChaseCCSpiersDEArthingtonJDet al

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Recent studies have shown that circulating DPP-4 plays a role in obesity and cardiovascular diseases, and may represent an important molecular link between obesity, diabetes, and cardiovascular disease (Rhrborn et al., 2015)

[37] [38] This caused diabetes research to shift towards other therapeutic options such as targeting the GLP-1 receptor, which then led to the development of GLP-1 receptor agonists