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When optimized and properly administered, B12 plays a crucial role in everything from red blood cell production to nerve function to metabolism

Individuals with conditions that affect their small intestine, such as Crohns disease and Celiac disease, may benefit from B12 supplementation, as well as those individuals who are on medications that affect B12 absorption, says Gans

While it may cause slightly more discomfort than the upper buttocks, it's generally easy to access and inject

While those can certainly play a role, dehydration is an often-overlooked contributor

In the body, high concentrations are found in skeletal muscles and the liver, brain, kidney, and heart

However, none of the studies reported on hematological or clinical outcomes