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DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A

Biochem Biophys Res Commun 231:488493 Aureli T, Puccetti C, Di Cocco ME, Arduini A, Ricciolini R, Scalibastri M, Manetti C, Conti F (1999) Entry of [(1,2-13C2)acetyl]-l-carnitine in liver tricarboxylic acid cycle and lipogenesis: a study by 13 C NMR spectroscopy in conscious, freely moving rats

This study showed that L-carnitine supplements were particularly effective for obese individuals

These effects come from sustained elevation of IGF-1 to 400-600 ng/mL for months or years

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