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Some researchers skip priming (drawing a small amount and pushing it back, or tapping out air bubbles thoroughly) and end up injecting mostly air for their first dose

In some cases, it can lead to new problems such as paranoia or aggression

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10.1007/s11357-024-01494-5 75 Valdes-TresancoM

Because the nutrient is protected, the question of "with food or without" becomes less urgent